![]() Labs that perform MOG live cell-based assay: Some studies have shown a correlation of persistent positive antibodies with further attacks. In a patient with positive MOG antibodies at a first attack, repeat testing every 6-12 months may be considered. If the diagnosis MOG-spectrum disease is suspected in a child, the investigation of choice is a live cell-based assay ideally performed a specialized laboratory.ĭifferent techniques are used to determine the level of MOG- abs in serum, which every laboratory has to specify in their reports. The presence of MOG antibodies can affect diagnosis, treatment choices, and prognosis. The precise role of MOG abs is unclear, and research suggests that the integrity of the myelin sheath is affected leading to a transient functional impairment of nerve conduction in the affected areas. Importantly, studies showed that in children who subsequently develop MS only rarely have MOG abs in serum and if present initially, MOG abs do disappear in the course of the disease. Adults may present with transverse myelitis or neuromyelitis optica. Young children have more often the clinical picture of ADEM and adolescents have an inflammation of the optic nerves. Several studies have demonstrated that the age of the affected child influences the clinical presentation. NMO-SD in the absence of AQP4 abs, is recurrent isolated or bilateral ON and in selected patients who do not fit one of the mentioned disease categories.Ĭhildren can have widespread involvement of primarily the white matter structures affecting many different areas of the central nervous system including the myelin. Myelin-oligodendrocyte-glycoprotein (MOG) antibodies (abs) can be found in the serum for nearly one-third of all children with almost all forms of demyelinating disorders, but are found particularly with children with acute disseminated encephalomyelitis (ADEM).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |